Article
Mutations in TMC1 are a common cause of DFNB7/11 hearing loss in the Iranian population.
The Annals of otology, rhinology, and laryngology - 1 Dec 2010
Hildebrand Michael S, Kahrizi Kimia, Bromhead Catherine J, Shearer A Eliot, Webster Jennifer A, Khodaei Hossein, Abtahi Rezvan, Bazazzadegan Niloofar, Babanejad Mojgan, Nikzat Nooshin, Kimberling William J, Stephan Dietrich, Huygen Patrick L M, Bahlo Melanie, Smith Richard J H, Najmabadi Hossein
Abstract excerpt
OBJECTIVES: We investigated the cause of autosomal recessive nonsyndromic hearing loss (ARNSHL) that segregated in 2 consanguineous Iranian families. METHODS: Otologic and audiometric examinations were performed on affected members of each family. Genome-wide parametric multipoint linkage mapping using a recessive model was performed with Affymetrix 50K GeneChips or short tandem repeat polymorphisms. Direct...
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