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Article

Mutational effects on the folding dynamics of a minimized hairpin.

Biochemistry - 16 Apr 2013

Scian Michele, Shu Irene, Olsen Katherine A, Hassam Khalil, Andersen Niels H

Abstract excerpt

The fold stabilities and folding dynamics of a series of mutants of a model hairpin, KTW-NPATGK-WTE (HP7), are reported. The parent system and the corresponding DPATGK loop species display submicrosecond folding time constants. The mutational studies revealed that ultrafast folding requires both some prestructuring of the loop and a favorable interaction between the chain termini in the transition state. In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23521619
DOI: 10.1021/bi400146c
PMCID: PMC3646797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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