Article
A strain of Yersinia pestis with a mutator phenotype from the Republic of Georgia.
FEMS microbiology letters - 1 Jun 2013
Rajanna Chythanya, Ouellette Gary, Rashid Mohammed, Zemla Adam, Karavis Mark, Zhou Carol, Revazishvili Tamara, Redmond Brady, McNew Lauren, Bakanidze Lela, Imnadze Paata, Rivers Bryan, Skowronski Evan W, O'Connell Kevin P, Sulakvelidze Alexander, Gibbons Henry S
Abstract excerpt
We describe here a strain of Yersinia pestis, G1670A, which exhibits a baseline mutation rate elevated 250-fold over wild-type Y. pestis. The responsible mutation, a C to T substitution in the mutS gene, results in the transition of a highly conserved leucine at position 689 to arginine (mutS(L689R)). When the MutSL 689R protein of G1670A was expressed in a ΔmutS derivative of Y. pestis strain EV76, mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.