Article
Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes.
Biomaterials - 1 Jun 2013
Ma Xu, Zhou Jia, Zhang Cheng-Xiang, Li Xiu-Ying, Li Nan, Ju Rui-Jun, Shi Ji-Feng, Sun Meng-Ge, Zhao Wei-Yu, Mu Li-Min, Yan Yan, Lu Wan-Liang
Abstract excerpt
The recurrence of breast cancer is associated with drug-resistance of cancer stem cells (CSCs), while overexpression of cell membrane ATP-binding cassette (ABC) transporters and resistance of mitochondrial apoptosis-related proteins are responsible for the drug-resistance of CSCs. The targeting berberine liposomes were developed to modulate the resistant membrane and mitochondrial proteins of breast CSCs for the...
Topics
- ATP-Binding Cassette Transporters
- Animals
- Apoptosis Regulatory Proteins
- Berberine
- Breast Neoplasms
- Cell Death
- Cytochromes c
- Diagnostic Imaging
- Drug Resistance, Neoplasm
- Female