Article
Genomic determinants of fluoroquinolone resistance in Escherichia coli in Nigeria: dominance of QRDR mutations and limited contribution of PMQR in a cross-sectional study.
BMC medical genomics - 19 Jun 2026
Medugu Nubwa, Aworh Mabel Kamweli, Abdulraheem Khadija, Hull Dawn M, Harden Lyndy, Thakur Siddhartha
Abstract excerpt
BACKGROUND: Fluoroquinolone-resistant Escherichia coli is a major global clinical threat, particularly in low- and middle-income countries like Nigeria. However, the full genomic landscape, including the relative contributions of chromosomal mutations, plasmid-mediated resistance, and the role of high-risk clones, remains poorly characterized in this setting. This study aimed to define the genomic mechanisms,...
Read the complete abstract on PubMedTopics
- Escherichia coli
- Mutation
- Fluoroquinolones
- Drug Resistance, Bacterial
- Nigeria
- Cross-Sectional Studies