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Article

Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds.

Biomaterials - 1 Jun 2013

Garg Koyal, Pullen Nicholas A, Oskeritzian Carole A, Ryan John J, Bowlin Gary L

Abstract excerpt

In this study, we investigated the effect of fiber and pore size of an electrospun scaffold on the polarization of mouse bone marrow-derived macrophages (BMMΦs) towards regenerative (M2) or inflammatory (M1) phenotypes. BMMΦs were seeded on Polydioxanone (PDO) scaffolds electrospun from varying polymer concentrations (60, 100, and 140 mg/ml). Higher polymer concentrations yielded larger diameter fibers with...

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Identifiers

PMID: 23515178
DOI: 10.1016/j.biomaterials.2013.02.065
PMCID: PMC3623371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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