Article
Analysis of genes coding for CD46, CD55, and C4b-binding protein in patients with idiopathic, recurrent, spontaneous pregnancy loss.
European journal of immunology - 1 Jun 2013
Mohlin Frida C, Mercier Eric, Fremeaux-Bacchi Veronique, Liszewski M Kathryn, Atkinson John P, Gris Jean-Christophe, Blom Anna M
Abstract excerpt
Since a tightly regulated complement system is needed for a successful pregnancy, we hypothesized that alterations in complement inhibitors may be associated with idiopathic, recurrent miscarriage. We sequenced all exons coding for three complement inhibitors: C4b-binding protein (C4BP), CD46, and CD55 in 384 childless women with at least two miscarriages that could not be explained by known risk factors. Several...
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