Article
A single nucleotide polymorphism in the human bone morphogenetic protein-2 gene (109T > G) affects the Smad signaling pathway and the predisposition to ossification of the posterior longitudinal ligament of the spine.
Chinese medical journal - 1 Mar 2013
Yan Liang, Chang Zhen, Liu Yang, Li Yi-Bing, He Bao-Rong, Hao Ding-Jun
Abstract excerpt
BACKGROUND: Although various systemic and local factors such as abnormal carbohydrate or calcium metabolism, aging, and hormonal disturbances have been suggested as causes of ossification of the posterior longitudinal ligament (OPLL), the etiology of OPLL is not fully understood. The purpose of this study was to investigate whether bone morphogenetic protein (BMP)-2 is a candidate gene to modify the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.