Article
Identification of rare copy number variants in high burden schizophrenia families.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2013
Van Den Bossche Maarten J, Strazisar Mojca, Cammaerts Sophia, Liekens Anthony M, Vandeweyer Geert, Depreeuw Veerle, Mattheijssens Maria, Lenaerts An-Sofie, De Zutter Sonia, De Rijk Peter, Sabbe Bernard, Del-Favero Jurgen
Abstract excerpt
Over the last years, genome-wide studies consistently showed an increased burden of rare copy number variants (CNVs) in schizophrenia patients, supporting the "common disease, rare variant" hypothesis in at least a subset of patients. We hypothesize that in families with a high burden of disease, and thus probably a high genetic load influencing disease susceptibility, rare CNVs might be involved in the etiology...
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