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Article

Role of RNF4 in the ubiquitination of Rta of Epstein-Barr virus.

The Journal of biological chemistry - 3 May 2013

Yang Ya-Chun, Yoshikai Yushi, Hsu Shih-Wei, Saitoh Hisato, Chang Li-Kwan

Abstract excerpt

Epstein-Barr virus (EBV) encodes a transcription factor, Rta, which is required to activate the transcription of EBV lytic genes. This study demonstrates that treating P3HR1 cells with a proteasome inhibitor, MG132, causes the accumulation of SUMO-Rta and promotes the expression of EA-D. GST pulldown and coimmunoprecipitation studies reveal that RNF4, a RING-domain-containing ubiquitin E3 ligase, interacts with...

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Source

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Identifiers

PMID: 23504328
DOI: 10.1074/jbc.M112.413393
PMCID: PMC3642330

Genes

RNF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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