Article
Identification of conserved neutralizing linear epitopes within the VP1 protein of coxsackievirus A16.
Vaccine - 19 Apr 2013
Shi Jinping, Huang Xulin, Liu Qingwei, Huang Zhong
Abstract excerpt
Coxsackievirus A16 (CA16) is a major causative agent of hand, foot, and mouth disease. Immunization with inactivated whole-virus or recombinant virus-like particles (VLP) of CA16 elicits neutralizing antibodies that protect mice against lethal challenge. However, the epitope/s responsible for this induction has not been determined. In this investigation, we identified six neutralizing linear epitopes of CA16. A...
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