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Article

The expression of lysyl‐oxidase gene family members in myeloproliferative neoplasms

8 Feb 2013

Abstract excerpt

Myeloproliferative neoplasms (MPNs) are malignant disorders originating from clonal expansion of a single neoplastic stem cell and characteristically show an increase in bone marrow reticulin fibers. Lysyl oxidases (LOXs) are copper-dependent amine oxidases that play a critical role in the biogenesis of connective tissue by crosslinking extracellular matrix proteins, collagen and elastin. Expression of LOX gene...

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PMID: 23494965
DOI: 10.1002/ajh.23409

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