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[Possible origin and evolution of enzymatic methylation of eukaryotic DNA. Methylation of cytosine residues in 3 palindromic families: RYRY, YYRR, and YYRYRR].

Molekuliarnaia biologiia - 1 Jan 2000

Mazin A L, Vaniushin B F

Abstract excerpt

Data on nearest neighbors of 5-methylcytosine residues in eukaryotic DNA were analyzed. It was found that the methylation sites C*G and C*NG may be located in three palindromic families: RYRY, YYRR and YYRYRR. It was shown that all the methylated sequences in these DNAs can appear as a result of 5-MeC----T substitutions, proceeding by deamination of 5-MeC residues in the "prototype" sites of each of these...

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PMID: 2348823

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