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Article

Gonadal Expression of Foxo1, but Not Foxo3, Is Conserved in Diverse Mammalian Species1

14 Mar 2013

Abstract excerpt

The Foxos are key effectors of the PI3K/Akt signaling pathway and regulate diverse physiologic processes. Two of these factors, Foxo1 and Foxo3, serve specific roles in reproduction in the mouse. Foxo3 is required for suppression of primordial follicle activation in females, while Foxo1 regulates spermatogonial stem cell maintenance in males. In the mouse ovary, Foxo1 is highly expressed in somatic cells (but not...

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PMID: 23486915
DOI: 10.1095/biolreprod.112.105791

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