Article
Metallothioneins I/II expression in rat strains with genetically different susceptibility to experimental autoimmune encephalomyelitis.
Neuroimmunomodulation - 1 Jan 2013
Grubić-Kezele Tanja, Jakovac Hrvoje, Tota Marin, Canadi-Jurešić Gordana, Barac-Latas Vesna, Milin Cedomila, Radošević-Stašić Biserka
Abstract excerpt
OBJECTIVES: Compared to the Dark Agouti (DA), the Albino Oxford (AO) rat strain exhibits lower susceptibility to the induction of experimental autoimmune encephalomyelitis (EAE). Here, we investigated the potential contribution of the heavy metal-binding proteins metallothioneins (MTs) I/II to these effects. METHODS: Rats were immunized with bovine brain homogenate emulsified in complete Freund's adjuvant or only...
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