Article
Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency.
BioMed research international - 1 Jan 2013
Ventura Annamaria, Brunetti Giacomina, Colucci Silvia, Oranger Angela, Ladisa Filomena, Cavallo Luciano, Grano Maria, Faienza Maria Felicia
Abstract excerpt
21-Hydroxylase deficiency (21-OHD) is the most common cause of congenital adrenal hyperplasia (CAH), resulting from deletions or mutations of the P450 21-hydroxylase gene (CYP21A2). Children with 21-OHD need chronic glucocorticoid (cGC) therapy, both to replace congenital deficit in cortisol synthesis and to reduce androgen secretion by adrenal cortex. GC-induced osteoporosis (GIO) is the most common form of...
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