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Article

Clinical features suggestive of non-classical 21-hydroxylase deficiency in children presenting with precocious pubarche.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2012

Bizzarri Carla, Crea Francesca, Marini Romana, Benevento Danila, Porzio Ottavia, Ravà Lucilla, Cappa Marco

Abstract excerpt

Precocious pubarche (PP) is defined as the onset of pubic hair at 8 years of age in girls and at 9 years of age in boys. PP is idiopathic (IPP) in most children, but it is the earliest manifestation of non-classical congenital adrenal hyperplasia owing to steroid 21-hydroxylase deficiency (NC21OHD) in 5%-20% of cases. 17-Hydroxyprogesterone (17OHP) levels after ACTH stimulation test are used to distinguish the...

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Share to 17-alpha-Hydroxyprogesterone
Share to Adrenal Hyperplasia, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adrenocorticotropic Hormone

Share to Child, Preschool

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Share to Puberty, Precocious

Share to Steroid 21-Hydroxylase

Source

Identifiers

PMID: 23329749
DOI: 10.1515/jpem-2012-0241

Genes

IPP
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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