Article
The modulation of endothelial cell morphology, function, and survival using anisotropic nanofibrillar collagen scaffolds.
Biomaterials - 1 May 2013
Huang Ngan F, Okogbaa Janet, Lee Jerry C, Jha Arshi, Zaitseva Tatiana S, Paukshto Michael V, Sun John S, Punjya Niraj, Fuller Gerald G, Cooke John P
Abstract excerpt
Endothelial cells (ECs) are aligned longitudinally under laminar flow, whereas they are polygonal and poorly aligned in regions of disturbed flow. The unaligned ECs in disturbed flow fields manifest altered function and reduced survival that promote lesion formation. We demonstrate that the alignment of the ECs may directly influence their biology, independent of fluid flow. We developed aligned nanofibrillar...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.