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Article

P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Dec 2013

Ciofu Oana, Johansen Helle Krogh, Aanaes Kasper, Wassermann Tina, Alhede Morten, von Buchwald Christian, Høiby Niels

Abstract excerpt

BACKGROUND: Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations. METHODS: We studied the genetic basis of...

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PMID: 23478131
DOI: 10.1016/j.jcf.2013.02.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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