Article
Phenotypes selected during chronic lung infection in cystic fibrosis patients: implications for the treatment of Pseudomonas aeruginosa biofilm infections.
FEMS immunology and medical microbiology - 1 Jul 2012
Ciofu Oana, Mandsberg Lotte F, Wang Hengzhuang, Høiby Niels
Abstract excerpt
During chronic lung infection of patients with cystic fibrosis, Pseudomonas aeruginosa can survive for long periods of time under the challenging selective pressure imposed by the immune system and antibiotic treatment as a result of its biofilm mode of growth and adaptive evolution mediated by genetic variation. Mucoidy, hypermutability and acquirement of mutational antibiotic resistance are important adaptive...
Topics
- Anti-Bacterial Agents
- Biofilms
- Chronic Disease
- Cystic Fibrosis
- Humans
- Lung
- Phenotype
- Pseudomonas Infections
- Pseudomonas aeruginosa
- Selection, Genetic
- beta-Lactams