Article
Rapid adaptation drives invasion of airway donor microbiota by Pseudomonas after lung transplantation.
Scientific reports - 17 Jan 2017
Beaume M, Köhler T, Greub G, Manuel O, Aubert J-D, Baerlocher L, Farinelli L, Buckling A, van Delden C
Abstract excerpt
In cystic fibrosis (CF) patients, chronic airway infection by Pseudomonas leads to progressive lung destruction ultimately requiring lung transplantation (LT). Following LT, CF-adapted Pseudomonas strains, potentially originating from the sinuses, may seed the allograft leading to infections and reduced allograft survival. We investigated whether CF-adapted Pseudomonas populations invade the donor microbiota and...
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