Article
Comparative studies of Acyl-CoA dehydrogenases for monomethyl branched chain substrates in amino acid metabolism.
Bioorganic chemistry - 1 Apr 2013
Liu Xiaojun, Wu Long, Deng Guisheng, Chen Gong, Li Nan, Chu Xiusheng, Li Ding
Abstract excerpt
Short/branched chain acyl-CoA dehydrogenase (SBCAD), isovaleryl-CoA dehydrogenase (IVD), and isobutyryl-CoA dehydrogenase (IBD) are involved in metabolism of isoleucine, leucine, and valine, respectively. These three enzymes all belong to acyl-CoA dehydrogenase (ACD) family, and catalyze the dehydrogenation of monomethyl branched-chain fatty acid (mmBCFA) thioester derivatives. In the present work, the catalytic...
Topics
- Acyl-CoA Dehydrogenase
- Amino Acid Sequence
- Amino Acids, Branched-Chain
- Animals
- Fatty Acids
- Isovaleryl-CoA Dehydrogenase
- Kinetics
- Liver
- Molecular Sequence Data
- Mutation
- Oxidoreductases Acting on CH-CH Group Donors
- Rats
- Recombinant Proteins
- Sequence Alignment