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Article

Structural basis of RIP1 inhibition by necrostatins.

Structure (London, England : 1993) - 5 Mar 2013

Xie Tian, Peng Wei, Liu Yexing, Yan Chuangye, Maki Jenny, Degterev Alexei, Yuan Junying, Shi Yigong

Abstract excerpt

Necroptosis is a cellular mechanism that mediates necrotic cell death. The receptor-interacting serine/threonine protein kinase 1 (RIP1) is an essential upstream signaling molecule in tumor-necrosis-factor-α-induced necroptosis. Necrostatins, a series of small-molecule inhibitors, suppress necroptosis by specifically inhibiting RIP1 kinase activity. Both RIP1 structure and the mechanisms by which necrostatins...

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Identifiers

PMID: 23473668
DOI: 10.1016/j.str.2013.01.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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