Article
InterAKTions with FKBPs--mutational and pharmacological exploration.
PloS one - 1 Jan 2013
Fabian Anne-Katrin, März Andreas, Neimanis Sonja, Biondi Ricardo M, Kozany Christian, Hausch Felix
Abstract excerpt
The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt, which was associated with reduced chemoresistance. Here we show that in addition to FKBP51 several other members of the FKBP family bind directly to Akt. FKBP51...
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