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Article

Proportionally more deleterious genetic variation in European than in African populations.

Nature - 21 Feb 2008

Lohmueller Kirk E, Indap Amit R, Schmidt Steffen, Boyko Adam R, Hernandez Ryan D, Hubisz Melissa J, Sninsky John J, White Thomas J, Sunyaev Shamil R, Nielsen Rasmus, Clark Andrew G, Bustamante Carlos D

Abstract excerpt

Quantifying the number of deleterious mutations per diploid human genome is of crucial concern to both evolutionary and medical geneticists. Here we combine genome-wide polymorphism data from PCR-based exon resequencing, comparative genomic data across mammalian species, and protein structure predictions to estimate the number of functionally consequential single-nucleotide polymorphisms (SNPs) carried by each of...

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Identifiers

PMID: 18288194
DOI: 10.1038/nature06611
PMCID: PMC2923434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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