Article
Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women.
Breast cancer research and treatment - 1 Apr 2013
Lajin Bassam, Alhaj Sakur Amir, Alachkar Amal
Abstract excerpt
Apoptosis is a major protective mechanism against cancer. The tumor suppressor protein p53 is the central protein in the apoptotic pathway and was shown to harbor mutations in a considerable fraction of breast cancer tumors. The NQO1 was shown to act as a p53 stabilizer and was suggested to play an important role in the protection against carcinogenic catechol estrogens. Functional polymorphisms in TP53 and NQO1...
Topics
- Adult
- Aged
- Apoptosis Regulatory Proteins
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Case-Control Studies
- Epistasis, Genetic
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease