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Article

Testosterone Levels Influence Mouse Fetal Leydig Cell Progenitors Through Notch Signaling1

6 Mar 2013

Abstract excerpt

Leydig cells are the steroidogenic lineage of the mammalian testis that produces testosterone, a key hormone required throughout male fetal and adult life for virilization and spermatogenesis. Both fetal and adult Leydig cells arise from a progenitor population in the testis interstitium but are thought to be lineage-independent of one another. Genetic evidence indicates that Notch signaling is required during...

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PMID: 23467742
DOI: 10.1095/biolreprod.112.106138

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