Article
The somatic affairs of BRAF: tailored therapies for advanced malignant melanoma and orphan non-V600E (V600R-M) mutations.
Journal of clinical pathology - 1 May 2013
Ponti Giovanni, Pellacani Giovanni, Tomasi Aldo, Gelsomino Fabio, Spallanzani Andrea, Depenni Roberta, Al Jalbout Samer, Simi Lisa, Garagnani Lorella, Borsari Stefania, Conti Andrea, Ruini Cristel, Fontana Annalisa, Luppi Gabriele
Abstract excerpt
BRAF V600R-M-D are uncommon mutations, not included in the experimental protocols of BRAF selective inhibitors. We report the evaluation of correlations among different types of BRAF somatic mutations in melanoma and their management with BRAF inhibitors. 21 patients with BRAF mutated metastatic melanoma were enrolled in the protocol with BRAF inhibitors for compassionate use at the University of Modena. Hot spot...
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