Article
Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2013
Pearce Celeste Leigh, Rossing Mary Anne, Lee Alice W, Ness Roberta B, Webb Penelope M, Chenevix-Trench Georgia, Jordan Susan M, Stram Douglas A, Chang-Claude Jenny, Hein Rebecca, Nickels Stefan, Lurie Galina, Thompson Pamela J, Carney Michael E, Goodman Marc T, Moysich Kirsten, Hogdall Estrid, Jensen Allan, Goode Ellen L, Fridley Brooke L, Cunningham Julie M, Vierkant Robert A, Weber Rachel Palmieri, Ziogas Argyrios, Anton-Culver Hoda, Gayther Simon A, Gentry-Maharaj Aleksandra, Menon Usha, Ramus Susan J, Brinton Louise, Wentzensen Nicolas, Lissowska Jolanta, Garcia-Closas Montserrat, Massuger Leon F A G, Kiemeney Lambertus A L M, Van Altena Anne M, Aben Katja K H, Berchuck Andrew, Doherty Jennifer A, Iversen Edwin, McGuire Valerie, Moorman Patricia G, Pharoah Paul, Pike Malcolm C, Risch Harvey, Sieh Weiva, Stram Daniel O, Terry Kathryn L, Whittemore Alice, Wu Anna H, Schildkraut Joellen M, Kjaer Susanne K
Abstract excerpt
BACKGROUND: There are several well-established environmental risk factors for ovarian cancer, and recent genome-wide association studies have also identified six variants that influence disease risk. However, the interplay between such risk factors and susceptibility loci has not been studied. METHODS: Data from 14 ovarian cancer case-control studies were pooled, and stratified analyses by each environmental risk...
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