Article
Differences in transcript levels of ABC transporters between pancreatic adenocarcinoma and nonneoplastic tissues.
Pancreas - 1 May 2013
Mohelnikova-Duchonova Beatrice, Brynychova Veronika, Oliverius Martin, Honsova Eva, Kala Zdenek, Muckova Katarina, Soucek Pavel
Abstract excerpt
OBJECTIVES: The aim of this study was to evaluate transcript levels of all 49 human ATP-binding cassette transporters (ABCs) in one of the most drug-resistant cancers, namely, the pancreatic ductal adenocarcinoma (PDAC). Association of ABCs levels with clinical-pathologic characteristics and KRAS mutation status was followed as well. METHODS: Tumors and adjacent nonneoplastic tissues were obtained from 32...
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