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Article

Expression and promoter methylation analysis of ATP-binding cassette genes in pancreatic cancer

28 Sept 2011

Abstract excerpt

We investigated the relationship of ABCB1/MDR1, ABCC1/MRP1 and ABCG2/BCRP expression and promoter methylation with pancreatic cancer tumorigenesis and drug resistance. Gemcitabine-resistant pancreatic cancer cells, SW1990/GZ (33.3-fold increased resistance), were obtained by treating SW1990 cells with gemcitabine. The expression of ABCB1/MDR1, ABCC1/MRP1 and ABCG2/BCRP was determined by quantitative real-time...

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PMID: 21956451
DOI: 10.3892/or.2011.1475

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