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[Isolation of high osmotic-tolerant mutants of Escherichia coli for succinic acid production by metabolic evolution].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 Nov 2012

Zhang Changqing, Gou Dongmei, Mei Jiajun, Liu Rongming, Ma Jiangfeng, Chen Kequan, Zhu Jianguo, Jiang Min

Abstract excerpt

Succinic acid production was inhibited by high osmotic pressure caused by the accumulation of sodium ions in the process of two-stage fermentation by Escherichia coli using Na2CO3 as the pH regulator. To enhance the resistance of this strain to osmotic stress, the possibility to isolate high NaCl-tolerant mutant strain of Escherichia coli for succinic acid production by metabolic evolution was investigated. The...

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PMID: 23457786

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