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Article

Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells.

FEBS letters - 2 Apr 2013

Prabhu Anika Vinayak, Krycer James Robert, Brown Andrew John

Abstract excerpt

Prostate metabolism is unique, characterised by cholesterol accumulation and reduced respiration. Are these related? We modulated cholesterol levels and despite changes in mitochondrial cholesterol content, we saw no effects on lactate production or respiration. Instead, these features may be related via sterol regulatory element-binding protein 2 (SREBP-2), the master transcriptional regulator of cholesterol...

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Identifiers

PMID: 23454642
DOI: 10.1016/j.febslet.2013.02.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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