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Article

Association of the ENPP1 rs997509 polymorphism with obesity in South African mixed ancestry learners.

East African medical journal - 1 Aug 2010

Matsha T, Fanampe, Yako Y, Hassan S, Hoffmann M, Van Der Merwe L, Erasmus R T

Abstract excerpt

BACKGROUND: The Ectonucleotide Pyrophosphatase Phosphodiesterasel (ENPP1) polymorphisms have been associated with metabolic traits. There is no data on the effect of ENPP1 in South African children or adults. OBJECTIVE: To investigate the role of K121Q (rs1044498), rs997509 and rs9402349 in obesity and other components of the metabolic syndrome. DESIGN: A case-control study. SUBJECTS: Sixty four obese and 64 lean...

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Source

Identifiers

PMID: 23451554

Genes

ENPP1

Variants

rs1044498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of the ENPP1 rs997509 polymorphism with obesity in South African mixed ancestry learners.PMID 23451554Read ↗

Contribution of ENPP1, TCF7L2, and FTO polymorphisms to type 2 diabetes in mixed ancestry ethnic population of South Africa.Semantic proximity Read ↗

ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children.Semantic proximity Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.Semantic proximity Read ↗

Association of K121Q polymorphism in ENPP1 (PC-1) with BMI in Caucasian and African-American adults.Semantic proximity Read ↗

New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals.Semantic proximity Read ↗

Further evidence for the role of ENPP1 in obesity: association with morbid obesity in Finns.Semantic proximity Read ↗

The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population.Semantic proximity Read ↗

Association of cocaine- and amphetamine-related transcript, leptin and leptin receptor gene polymorphisms with anthropometric obesity phenotype indicators in South African learners.Semantic proximity Read ↗

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.Semantic proximity Read ↗

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Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants.Semantic proximity Read ↗

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