Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis.

Cancer research - 1 May 2013

Fu Leiping, Wang Gang, Shevchuk Maria M, Nanus David M, Gudas Lorraine J

Abstract excerpt

Renal cell carcinoma (RCC) is the most common primary cancer arising from the kidney in adults, with clear cell renal cell carcinoma (ccRCC) representing approximately 75% of all RCCs. Increased expression of the hypoxia-induced factors-1α (HIF1α) and HIF2α has been suggested as a pivotal step in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Kidney Neoplasms
Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Glycogen

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Kidney

Share to Kidney Tubules

Source

Open in PubMed Open full text

Identifiers

PMID: 23447580
DOI: 10.1158/0008-5472.CAN-12-3983
PMCID: PMC3642229

Genes

MKI67

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23447580-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis.PMID 23447580Read ↗

Generation of a Mouse Model of Von Hippel–Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1αSemantic proximity Read ↗

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in miceSemantic proximity Read ↗

The role of HIF1α in renal cell carcinoma tumorigenesis.Semantic proximity Read ↗

Formation of Renal Cysts and Tumors in <i>Vhl/Trp53</i> -Deficient Mice Requires HIF1α and HIF2αSemantic proximity Read ↗

Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathwaySemantic proximity Read ↗

Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD)Semantic proximity Read ↗

The Microphthalmia-Associated Transcription Factor p.E318K Mutation Does Not Play a Major Role in Sporadic Renal Cell Tumors from Caucasian Patients.Semantic proximity Read ↗

Expression and Characterization of Hypoxia-Inducible Factor (HIF)-3α in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3αSemantic proximity Read ↗

Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma.Semantic proximity Read ↗

HNF1alpha controls renal glucose reabsorption in mouse and man.Semantic proximity Read ↗

Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.