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Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer

27 Feb 2013

Abstract excerpt

TMPRSS2-ERG rearrangements occur in approximately 50% of prostate cancers and therefore represent one of the most frequently observed structural rearrangements in all cancers. However, little is known about the genomic architecture of such rearrangements. We therefore designed and optimized a pipeline involving target capture of TMPRSS2 and ERG genomic sequences coupled with paired-end next-generation sequencing...

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PMID: 23447416
DOI: 10.1002/path.4186

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