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Article

Notch Pathway Activity Identifies Cells with Cancer Stem Cell–like Properties and Correlates with Worse Survival in Lung Adenocarcinoma

26 Feb 2013

Abstract excerpt

PURPOSE: The cancer stem cell theory postulates that tumors contain a subset of cells with stem cell properties of self-renewal, differentiation, and tumor initiation. The purpose of this study is to determine the role of Notch activity in identifying lung cancer stem cells. EXPERIMENTAL DESIGN: We investigated the role of Notch activity in lung adenocarcinoma using a Notch GFP reporter construct and a...

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PMID: 23444212
DOI: 10.1158/1078-0432.ccr-12-0370

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