Article
Fetal polymorphisms at the ABCB1-transporter gene locus are associated with susceptibility to non-syndromic oral cleft malformations.
European journal of human genetics : EJHG - 1 Dec 2013
Omoumi Ardeshir, Wang Zihua, Yeow Vincent, Wu-Chou Yah-Huei, Chen Philip K, Ruczinski Ingo, Cheng Joanne, Cheah Felicia S H, Lee Caroline G, Beaty Terri H, Chong Samuel S
Abstract excerpt
ATP-binding cassette (ABC) proteins in the placenta regulate fetal exposure to xenobiotics. We hypothesized that functional polymorphisms in ABC genes influence risk for non-syndromic oral clefts (NSOC). Both family-based and case-control studies were undertaken to evaluate the association of nine potentially functional single-nucleotide polymorphisms within four ABC genes with risk of NSOC. Peripheral blood DNA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.