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Article

Truncation and Mutation of a Transferrin Receptor Aptamer Enhances Binding Affinity.

Nucleic acid therapeutics - 1 Dec 2016

Macdonald Joanna, Houghton Patrick, Xiang Dongxi, Duan Wei, Shigdar Sarah

Abstract excerpt

Aptamers are proving their utility in a number of applications. However, to be easily functionalized, their structure needs to be simplified. Therefore, we sought to truncate a 50-nucleotide aptamer specific to the transferrin receptor to its smallest functional unit using rational engineering of the predicted two-dimensional structure of the longer parent sequence. In addition, mutations were introduced into the...

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Identifiers

PMID: 27500826
DOI: 10.1089/nat.2015.0585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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