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Article

Dissecting the Genetic Architecture of Tanning and Sunburn as Skin Cancer Risk Factors.

The Journal of investigative dermatology - 1 May 2026

Helder Marloes, Pandeya Nirmala, Ingold Nathan, Seviiri Mathias, Olsen Catherine M, Whiteman David C, Law Matthew H

Abstract excerpt

UVR is the main modifiable risk factor for skin cancer, causing direct DNA damage. Genetic factors influence UV-mediated skin cancer risk by modulating the skin's response to UVR, typically seen as acute inflammation (sunburn) or a delayed increase of melanin production (tanning). Although biologically distinct, most studies to date have not differentiated between these outcomes, conflating their genetic risk...

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Identifiers

PMID: 41167550
DOI: 10.1016/j.jid.2025.10.585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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