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Article

The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus.

PLoS pathogens - 1 Feb 2013

Firon Arnaud, Tazi Asmaa, Da Cunha Violette, Brinster Sophie, Sauvage Elisabeth, Dramsi Shaynoor, Golenbock Douglas T, Glaser Philippe, Poyart Claire, Trieu-Cuot Patrick

Abstract excerpt

Group B Streptococcus (GBS), a common commensal of the female genital tract, is the leading cause of invasive infections in neonates. Expression of major GBS virulence factors, such as the hemolysin operon cyl, is regulated directly at the transcriptional level by the CovSR two-component system. Using a random genetic approach, we identified a multi-spanning transmembrane protein, Abx1, essential for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23436996
DOI: 10.1371/journal.ppat.1003179
PMCID: PMC3578759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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