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Article

The proteome of Toll-like receptor 3-stimulated human immortalized fibroblasts: implications for susceptibility to herpes simplex virus encephalitis.

The Journal of allergy and clinical immunology - 1 Apr 2013

Pérez de Diego Rebeca, Mulvey Claire, Crawford Mark, Trotter Matthew W B, Lorenzo Lazaro, Sancho-Shimizu Vanessa, Abel Laurent, Zhang Shen-Ying, Casanova Jean-Laurent, Godovac-Zimmermann Jasminka

Abstract excerpt

BACKGROUND: Inborn errors in Toll-like receptor 3 (TLR3)-IFN type I and III pathways have been implicated in susceptibility to herpes simplex virus encephalitis (HSE) in children, but most patients studied do not carry mutations in any of the genes presently associated with HSE susceptibility. Moreover, many patients do not display any TLR3-IFN-related fibroblastic phenotype. OBJECTIVE: To study other signaling...

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Identifiers

PMID: 23434283
DOI: 10.1016/j.jaci.2013.01.008
PMCID: PMC3640632

Genes

TLR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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