Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.

doi:10.1073/pnas.1216013110

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Article

Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 5 Mar 2013

Posch Christian, Moslehi Homayoun, Feeney Luzviminda, Green Gary A, Ebaee Anoosheh, Feichtenschlager Valentin, Chong Kim, Peng Lily, Dimon Michelle T, Phillips Thomas, Daud Adil I, McCalmont Timothy H, LeBoit Philip E, Ortiz-Urda Susana

Abstract excerpt

Activating mutations in the neuroblastoma rat sarcoma viral oncogene homolog (NRAS) gene are common genetic events in malignant melanoma being found in 15-25% of cases. NRAS is thought to activate both mitogen activated protein kinase (MAPK) and PI3K signaling in melanoma cells. We studied the influence of different components on the MAP/extracellular signal-regulated (ERK) kinase (MEK) and PI3K/mammalian target...

Topics

Animals
Antineoplastic Agents
Apoptosis
Cell Line, Tumor
Drug Synergism
Female
GTP Phosphohydrolases
Humans
MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanoma

Membrane Proteins

Mice

Mice, Nude

Mutation

Phosphoinositide-3 Kinase Inhibitors

Protein Kinase Inhibitors

Signal Transduction

TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 23431193
DOI: 10.1073/pnas.1216013110
PMCID: PMC3593920

Genes

NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23431193-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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