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Article

Dimerization of bacterial diaminopimelate epimerase is essential for catalysis.

The Journal of biological chemistry - 29 Mar 2013

Hor Lilian, Dobson Renwick C J, Downton Matthew T, Wagner John, Hutton Craig A, Perugini Matthew A

Abstract excerpt

Diaminopimelate (DAP) epimerase is involved in the biosynthesis of meso-DAP and lysine, which are important precursors for the synthesis of peptidoglycan, housekeeping proteins, and virulence factors in bacteria. Accordingly, DAP epimerase is a promising antimicrobial target. Previous studies report that DAP epimerase exists as a monomeric enzyme. However, we show using analytical ultracentrifugation, X-ray...

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Identifiers

PMID: 23426375
DOI: 10.1074/jbc.M113.450148
PMCID: PMC3610995

Genes

DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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