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Article

The dimerization domain in DapE enzymes is required for catalysis.

PloS one - 1 Jan 2014

Nocek Boguslaw, Starus Anna, Makowska-Grzyska Magdalena, Gutierrez Blanca, Sanchez Stephen, Jedrzejczak Robert, Mack Jamey C, Olsen Kenneth W, Joachimiak Andrzej, Holz Richard C

Abstract excerpt

The emergence of antibiotic-resistant bacterial strains underscores the importance of identifying new drug targets and developing new antimicrobial compounds. Lysine and meso-diaminopimelic acid are essential for protein production and bacterial peptidoglycan cell wall remodeling and are synthesized in bacteria by enzymes encoded within dap operon. Therefore dap enzymes may serve as excellent targets for...

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PMID: 24806882
DOI: 10.1371/journal.pone.0093593
PMCID: PMC4012986

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Source receipt: pubmed, retrieved 7 Sept 2026.

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