Article
Using BioBin to explore rare variant population stratification.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2013
Moore Carrie B, Wallace John R, Frase Alex T, Pendergrass Sarah A, Ritchie Marylyn D
Abstract excerpt
Rare variants (RVs) will likely explain additional heritability of many common complex diseases; however, the natural frequencies of rare variation across and between human populations are largely unknown. We have developed a powerful, flexible collapsing method called BioBin that utilizes prior biological knowledge using multiple publicly available database sources to direct analyses. Variants can be collapsed...
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