Article
Genome-wide survey of interindividual differences of RNA stability in human lymphoblastoid cell lines.
Scientific reports - 1 Jan 2013
Duan Jubao, Shi Jianxin, Ge Xijin, Dölken Lars, Moy Winton, He Deli, Shi Sandra, Sanders Alan R, Ross Jeff, Gejman Pablo V
Abstract excerpt
The extent to which RNA stability differs between individuals and its contribution to the interindividual expression variation remain unknown. We conducted a genome-wide analysis of RNA stability in seven human HapMap lymphoblastoid cell lines (LCLs) and analyzed the effect of DNA sequence variation on RNA half-life differences. Twenty-six percent of the expressed genes exhibited RNA half-life differences between...
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