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Article

Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles.

Investigative ophthalmology & visual science - 13 Mar 2013

Kuchtey John, Kunkel Jessica, Esson Douglas, Sapienza John S, Ward Daniel A, Plummer Caryn E, Gelatt Kirk N, Kuchtey Rachel W

Abstract excerpt

PURPOSE: Previously, we mapped the disease locus in the beagle model of autosomal recessive primary open angle glaucoma (POAG) to a 4-Mb interval on chromosome 20, and identified a Gly661Arg variant in ADAMTS10 as the candidate disease-causing variant. The purpose of this study was to test the hypothesis that the Gly661Arg variant of ADAMTS10 causes glaucoma by genotyping dogs of various breeds affected and...

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Identifiers

PMID: 23422823
DOI: 10.1167/iovs.12-10796
PMCID: PMC3604907

Genes

ADAMTS10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Screening ADAMTS10 in dog populations supports Gly661Arg as the glaucoma-causing variant in beagles.PMID 23422823Read ↗

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