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Article

Excess breast cancer risk in first degree relatives of CHEK2∗1100delC positive familial breast cancer cases.

European journal of cancer (Oxford, England : 1990) - 1 May 2013

Adank Muriel A, Verhoef Senno, Oldenburg Rogier A, Schmidt Marjanka K, Hooning Maartje J, Martens John W M, Broeks Annegien, Rookus Matti, Waisfisz Quinten, Witte Birgit I, Jonker Marianne A, Meijers-Heijboer Hanne

Abstract excerpt

AIM: The CHEK2∗1100delC mutation confers a relative risk of two for breast cancer (BC) in the general population. This study aims to explore the excess cancer risk due to the CHEK2∗1100delC mutation within a familial non-BRCA1/2 breast cancer setting. PATIENTS AND METHODS: Cancer incidences were compared between first degree relatives of 107 familial breast cancer patients positive for the CHEK2∗1100delC mutation...

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Identifiers

PMID: 23415889
DOI: 10.1016/j.ejca.2013.01.009

Genes

CHEK2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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