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Article

A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.

The Journal of biological chemistry - 25 May 1990

Yarbrough W G, Quarmby V E, Simental J A, Joseph D R, Sar M, Lubahn D B, Olsen K L, French F S, Wilson E M

Abstract excerpt

The complete form of androgen insensitivity is an inherited X-linked syndrome in which genetic males fail to undergo masculinization in utero due to defective functioning of the androgen receptor (AR). The molecular basis of androgen insensitivity was investigated in the testicular feminized (Tfm) rat with this syndrome. AR mRNA size and amount, as well as nuclear AR protein revealed by immunocytochemistry,...

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PMID: 2341409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.PMID 2341409Read ↗

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A frame-shift mutation in the androgen receptor gene causes complete androgen insensitivity in the testicularfeminized mouseSemantic proximity Read ↗

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Response to treatment in patients with partial androgen insensitivity due to mutations in the DNA-binding domain of the androgen receptor.Semantic proximity Read ↗

Molecular defects of the androgen receptor.Semantic proximity Read ↗

A single-base substitution in exon 6 of the androgen receptor gene causing complete androgen insensitivity: the mutated receptor fails to transactivate but binds to DNA in vitro.Semantic proximity Read ↗

Androgen resistance associated with a mutation of the androgen receptor at amino acid 772 (Arg----Cys) results from a combination of decreased messenger ribonucleic acid levels and impairment of receptor function.Semantic proximity Read ↗

Amino acid substitutions in the DNA-binding domain of the human androgen receptor are a frequent cause of receptor-binding positive androgen resistance.Semantic proximity Read ↗

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Sex, infertility and the molecular biology of the androgen receptor.Semantic proximity Read ↗

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