Article
A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat.
The Journal of biological chemistry - 25 May 1990
Yarbrough W G, Quarmby V E, Simental J A, Joseph D R, Sar M, Lubahn D B, Olsen K L, French F S, Wilson E M
Abstract excerpt
The complete form of androgen insensitivity is an inherited X-linked syndrome in which genetic males fail to undergo masculinization in utero due to defective functioning of the androgen receptor (AR). The molecular basis of androgen insensitivity was investigated in the testicular feminized (Tfm...
Topics
- Amino Acid Sequence
- Androgens
- Animals
- Base Sequence
- Cell Line
- DNA
- Feminization
- Gene Amplification
- Humans
- Male
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Rats
- Rats, Mutant Strains
- Receptors, Androgen